According to different properties of fluorite ore, separation is mainly divided into flotation and magnetic separation-flotation. When iron grade is relatively low, generally adjust PH value of tailings by desulfurization in flotation process. New fatty acids collectors and new efficient depressants make fluorite mineral separate from other gangue. When iron grade is relatively high, firstly separate iron by magnetic separation, and the next process is desulfurization and flotation of fluorite ore.